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Histidine: The Amino Acid That Flips Charge Near Neutral pH
Most amino acids are either always charged or never charged in a normal lab solution. Histidine is the exception. Its ring has a pKa near 6, which means it flips between positive and neutral right in the range where many experiments take place.
What that means
- Below pH 6: mostly positive.
- Above pH 6: mostly neutral.
- Around pH 6: half and half.
Histidine in our catalog
| Peptide | Histidine count |
|---|---|
| GHK-Cu | 1 |
| Semax | 1 |
| Melanotan-1 | 1 |
| Melanotan-2 | 1 |
| BPC-157, KPV, DSIP, Tesamorelin | 0 |
Three jobs of histidine
Metal binding: the ring nitrogen grips metals, which is the key to GHK-Cu.
Buffering: it resists pH change near neutral.
Solubility: shifting charge changes how well a peptide dissolves.
Keep reading to see how this connects to storage conditions.
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For laboratory research use only. Not for human or veterinary use, and not intended to diagnose, treat, cure or prevent any condition. This article is educational and is not medical advice.
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